Prenatal diagnosis of partial trisomy 22 derived from a maternal t(11;22) (q23;q11).

SOU, S., TAKABAYASHI, T., SASAKI, H., SASAMOTO, K., SHINTAKU, Y., LI, Z.-J., OZAWA, N. and YAJIMA, A. Prenatal Diagnosis of Partial Trisomy 22 Derived from a Maternal t(11; 22) (q23; q11). Tohoku J. exp. Med., 1987, 153 (4), 389-393 - A fetus with partial trisomy 22 was detected by amniocentesis in a pregnant woman with balanced translocation, 46, XX, t(11; 22) (q23; q11). The aborted fetus had multiple congenital anomalies consisting of microcephaly, cleft lip and palate. The extra acrocentric chromosome was identified as der (22), t(11; 22)(q23; q11). The aborted fetus is compared with other trisomic cases described in literatures, and perinatal diagnosis of this case was discussed.