Results of Treatment of Angina Pectoris With Choline Theophyllinate by the Double-Blind Method

Article1 June 1956RESULTS OF TREATMENT OF ANGINA PECTORIS WITH CHOLINE THEOPHYLLINATE BY THE DOUBLE-BLIND METHODCHRIST ARAVANIS, M.D., ALDO A. LUISADA, M.D., F.A.C.P.CHRIST ARAVANIS, M.D.Search for more papers by this author, ALDO A. LUISADA, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-44-6-1111 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTreatment of angina pectoris still is a difficult problem of great practical importance. Even though rapidly acting drugs like nitroglycerin may give temporary relief, any drug causing a lasting subjective improvement and an increase of working capacity is of great interest to the practitioner.It has been stated that choline theophyllinate causes a marked and lasting improvement in cases with coronary heart disease and anginal pain, and that such improvement is far greater than that obtained with aminophylline. Moreover, the disadvantages encountered with aminophylline (gastric intolerance, gradually decreasing effect) were not found with the choline derivate. A sharp denial of...Bibliography1. BattermanGrossmanSchwimmerBlackman RCAJJAL: Treatment of congestive heart failure and anginal syndrome with choline theophyllinate, J. A. M. A. 157: 234, 1955. CrossrefMedlineGoogle Scholar2. Russek HI: Anginal syndrome and choline theophyllinate, J. A. M. A. 157: 751, 1955. CrossrefGoogle Scholar3. Russek HI: Vasodilator drugs and anginal syndrome, J. A. M. A. 158: 216, 1955. CrossrefGoogle Scholar4. Batterman RC: Drugs and anginal syndrome, J. A. M. A. 157: 1333, 1955. CrossrefGoogle Scholar5. LevyBruennWilliams RLHGNE: The modifying action of certain drugs upon the effects of induced anoxemia in patients with coronary insufficiency, Am. Heart J. 19: 639, 1940. CrossrefGoogle Scholar6. RussekSmithBaumNaegeleRegan HIRHWSCFFD: Influence of saline, papaverine, nitroglycerin and ethyl alcohol on electrocardiographic response to standard exercise in coronary disease, Circulation 1: 700, 1950. CrossrefGoogle Scholar7. RisemanSteinbergAltman JELAGE: Treatment of angina pectoris with cinchona alkaloids, Circulation 10: 809, 1954. CrossrefMedlineGoogle Scholar8. RussekUrbachDoernerZohman HIKFAABL: Choice of a coronary vasodilator drug in clinical practice, J. A. M. A. 153: 207, 1953. CrossrefMedlineGoogle Scholar9. RaabLepeschkin WE: Heart "sympathin," Circulation 1: 741, 1950. CrossrefGoogle Scholar10. RosenbergMichelson HNAL: The use of pentaerythritol tetranitrate in chronic coronary insufficiency, Am. J. M. Sc. 230: 254, 1955. CrossrefMedlineGoogle Scholar11. ControHaringGoldstein SOMW: Paradoxic action of amyl nitrite in coronary patients, Circulation 6: 250, 1952. CrossrefMedlineGoogle Scholar12. RussekUrbach HIKF: Paradoxical action of glyceryl trinitrate (nitroglycerin) in coronary patients, J. A. M. A. 158: 1017, 1955. CrossrefMedlineGoogle Scholar13. RussekZohmanDrummWeingartenDorset HIBLAEWVJ: Long-acting coronary vasodilator drugs: Metamine, Paveril, Nitroglyn, and Peritrate, Circulation 12: 169, 1955. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Chicago, Illinois*Received for publication November 21, 1955.From the Division of Cardiology of The Chicago Medical School and Mount Sinai Hospital.†From Athens, Greece. Research Associate in the Division of Cardiology.‡Associate Professor of Medicine and Director, Division of Cardiology, The Chicago Medical School and Mount Sinai Hospital, under a Teaching Grant of the National Heart Institute, U. S. Public Health Service. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEvidence-based medicine: Revisiting the pyramid of prioritiesProblems in the Evaluation of Drugs in ManEFFECT OF THEOPHYLLINE ON EXERCISE-INDUCED MYOCARDIAL ISCHAEMIAThe sympathogenic biochemical trigger mechanism of angina pectorisBibliographyCoronary Vasodilating Drugs 1 June 1956Volume 44, Issue 6Page: 1111-1122KeywordsAnginaCoronary heart diseaseDrugsElectrocardiographyHeartHospital medicineMedical servicesSedatives ePublished: 1 December 2008 Issue Published: 1 June 1956 PDF downloadLoading ...