Key result
Young men with Down's syndrome exhibit lower VO2max and altered hormonal responses during exercise.
Why the study?
Hormonal responses to exercise and their relation to exercise limitation in young men with Down's syndrome were not well understood.
Do altered hormonal responses to exercise explain reduced endurance performance in young men with Down's syndrome?
Case-Control (n=29)
Do altered hormonal responses to exercise explain reduced endurance performance in young men with Down's syndrome?
p-value: p=<0.05
Young men with Down's syndrome exhibit an altered endocrine profile at rest and during exercise, which may contribute to their reduced endurance performance.
Altered hormonal responses may limit endurance in DS; leaves open causal mechanisms and need for targeted intervention trials.
The aim of the present study was to analyse whether hormonal responses could explain an exercise limitation in Down's syndrome (DS). Fourteen young men with DS (mean age 22.5 +/- 0.7 years) and 15 controls (CONT, mean age 22.5 +/- 0.3 years) participated in the study. During a treadmill submaximal incremental test, blood samples were collected for determination of hormonal and metabolic variables. Compared to CONT, DS individuals showed lower VO(2max) (P < 0.05), and lower duration of submaximal incremental exercise (P < 0.001). At rest, DS individuals showed greater catecholamines, insulin and leptin values (P < 0.05), but lower testosteronemia and cortisolemia (P < 0.05), compared to CONT. During submaximal incremental tests, catecholamines and cortisol were not increased, whereas the insulin concentration of DS individuals was significantly higher (P < 0.01) compared to CONT. Glycaemia increased significantly at the end of submaximal incremental test for CONT but not for DS individuals (P < 0.01). Maximal fat oxidation was lower (P < 0.01), whereas non-esterified fatty acids concentrations rose significantly during submaximal exercise in DS individuals. These results indicate an altered hormonal response to exercise in DS individuals. This endocrine profile at rest and during exercise may limit endurance performance in DS individuals.
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Bricout et al. (2008) conducted a case-control in Down's syndrome (n=29). Down's syndrome vs. Controls was evaluated on VO2max (p=<0.05). Young men with Down's syndrome exhibited lower VO2max (P<0.05) and altered hormonal responses during submaximal exercise compared to controls, potentially limiting endurance performance.
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