Key result
UL4-rich Gynostemma pentaphyllum extract prevents diet-induced hepatic fat accumulation, inflammation, and fibrosis in mice.
Why the study?
The precise mechanism by which Gynostemma pentaphyllum extract confers benefits in NAFLD remains largely unknown.
Does UL4-rich Gynostemma pentaphyllum extract mitigate NASH progression in diet-induced NAFLD models?
Does UL4-rich Gynostemma pentaphyllum extract mitigate NASH progression in diet-induced NAFLD models?
UL4-rich Gynostemma pentaphyllum extract shows potential in preventing the development of fatty liver and its progression to NASH in preclinical models.
May support UL4-rich GPE in preclinical NASH models; leaves open human translation and clinical trials.
Nonalcoholic steatohepatitis (NASH) arises from nonalcoholic fatty liver disease (NAFLD) as a consequence of oxidative stress. Gynostemma pentaphyllum extract (GPE) is proven to be beneficial for patients suffering from NAFLD. However, the precise mechanism by which GPE confers these benefits remains largely unknown. The purpose of this study was to investigate the underlying mechanism and to determine whether supplementation with the newly discovered GPE gypenoside UL4 mitigates NASH progression. Male c57BL/6 mice were fed a normal chow diet, a methionine choline-deficient (MCD) diet, or an MCD diet supplemented with various doses of UL4-rich GPE for eight weeks. GPE supplementation suppressed oxidative stress induced by the MCD diet by increasing levels of sirtuin 6 and phase 2 anti-oxidant enzymes in mouse liver and HepG2 cells. Additionally, GPE supplementation prevented diet-induced hepatic fat accumulation, hepatocellular injury, inflammation, and fibrosis in mice fed the MCD diet. These results indicate the possible therapeutic potential of dietary supplementation of UL4-rich GPE in preventing the development of fatty liver and its progression to NASH.
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Bae et al. (2018) studied Nonalcoholic fatty liver disease (NAFLD) / Nonalcoholic steatohepatitis (NASH). UL4-rich Gynostemma pentaphyllum extract (GPE) vs. MCD diet alone was evaluated on Oxidative stress, hepatic fat accumulation, hepatocellular injury, inflammation, and fibrosis. Supplementation with UL4-rich Gynostemma pentaphyllum extract prevented diet-induced hepatic fat accumulation, hepatocellular injury, inflammation, and fibrosis in mice fed an MCD diet.
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