Key result
Increasing prematurity links to lower HRV at birth but does not predict 3-month cardiovascular development.
Why the study?
Pregnancy complications may have long-term offspring cardiac sequelae, but their association with neonatal heart rate variability and early cardiovascular development is unclear.
Do pregnancy complications alter neonatal heart rate variability at birth and predict cardiovascular development at 3 months?
Comparison
Pregnancy complications (prematurity, maternal hypertension, growth restriction) vs term infants
Design
Cohort study
Follow-up
3 months
Authors
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Neonatal HRV differences linked to pregnancy complications warrant caution; hypothesis-generating and leaves open predictive value for later cardiac risk.
Cohort (n=98)
No
Do pregnancy complications alter neonatal heart rate variability at birth and predict cardiovascular development at 3 months?
Effect estimate: B=0.99 (95% CI 0.43-1.54)
p-value: p=<0.001
Prematurity, but not maternal hypertension or growth restriction, is associated with altered cardiac autonomic function at birth, though this does not predict short-term cardiovascular developmental patterns.
Aye et al. (2018) conducted a cohort in Pregnancy complications (prematurity, maternal hypertension, small for gestational age) (n=98). Prematurity vs. Term birth was evaluated on Heart rate variability (rMSSD) at birth associated with gestational age (B=0.99, 95% CI 0.43-1.54, p=<0.001). Increasing prematurity was significantly associated with decreased heart rate variability at birth, including lower rMSSD (p < 0.001), but did not predict cardiovascular developmental patterns at 3 months.
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