Key result
Reduced HRV features including SDNN strongly correlate with higher EEG severity grades in neonatal HIE.
Why the study?
The relationship between heart rate variability and EEG grade of HIE as well as neurodevelopmental outcome in neonatal hypoxic ischemic encephalopathy was not well described.
Is heart rate variability associated with EEG grade and neurodevelopmental outcome in neonates with hypoxic ischemic encephalopathy?
Population
Healthy and encephalopathic full-term neonates assessed at 12-48 h after birth
Comparison
Heart rate variability features correlated with EEG grade and neurodevelopmental outcome
Design
Observational cohort study
Follow-up
2 years
Authors
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HRV metrics correlate with HIE severity and 2-year outcome; supports prospective validation as EEG complement but should not yet change practice.
Observational (n=61)
Yes
Is heart rate variability associated with EEG grade and neurodevelopmental outcome in neonates with hypoxic ischemic encephalopathy?
Effect estimate: r = -0.62 (95% CI -0.75 to -0.45)
p-value: p=<0.05
Heart rate variability assessed at 12-48 hours after birth correlates with HIE severity and 2-year neurodevelopmental outcomes, suggesting its potential as a prognostic tool.
Goulding et al. (2015) conducted an observational in Hypoxic ischemic encephalopathy (n=61). Hypoxic ischemic encephalopathy vs. Healthy neonates was evaluated on Correlation between standard deviation of the NN interval (SDNN) and EEG grade of encephalopathy (r = -0.62, 95% CI -0.75 to -0.45, p=<0.05). Heart rate variability features, including SDNN, were significantly reduced in neonates with hypoxic ischemic encephalopathy and negatively correlated with EEG severity grade (r = -0.62).
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