Key result
Serum neutralization and immunofluorescence fail to detect specific antibodies or immune complexes in mink encephalopathy.
Why the study?
Attempts to detect specific serum antibody or immune complexes in mink affected with transmissible mink encephalopathy were needed due to the disease's unusual nature and etiological agent properties.
Population
Mink affected with transmissible mink encephalopathy
Comparison
Serum neutralization and immunofluorescent procedures to detect antibodies
Design
Other study type
Authors
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Limits expectations for antibody-based diagnosis in prion diseases; leaves open alternative detection methods for transmissible encephalopathies.
The study failed to demonstrate specific antibodies or immune complexes in transmissible mink encephalopathy, highlighting the unusual nature of the etiological agent.
Marsh et al. (1970) studied this question. Serum neutralization and immunofluorescent procedures failed to demonstrate specific serum antibodies or immune complexes in the brains of mink with transmissible mink encephalopathy.
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