Key result
Maternal inheritance of FH shows no difference in offspring LDL cholesterol versus paternal inheritance.
Why the study?
Previous studies on whether offspring from hypercholesterolemic mothers have increased cardiovascular risk showed conflicting evidence and had limitations such as cohort size and sampling bias.
Does maternal inheritance of familial hypercholesterolemia increase cardiovascular risk markers compared to paternal inheritance in offspring?
Comparison
Offspring of FH mothers versus offspring of FH fathers
Design
Cohort study
Authors
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No LDL difference by parental FH inheritance; leaves open effects on other risk markers or outcomes.
Cohort (n=2,657)
Does maternal inheritance of familial hypercholesterolemia increase cardiovascular risk markers compared to paternal inheritance in offspring?
Mean Difference: 0.02 (95% CI -0.06–0.11)
p-value: p=0.60
Cardiovascular risk markers, including LDL cholesterol and c-IMT, do not differ significantly between offspring who inherit familial hypercholesterolemia from their mothers versus their fathers.
Kusters et al. (2013) conducted a cohort in Familial hypercholesterolemia (n=2,657). Maternal inheritance of familial hypercholesterolemia vs. Paternal inheritance of familial hypercholesterolemia was evaluated on LDL cholesterol (mean difference 0.02, 95% CI -0.06,0.11, p=0.60). Offspring of mothers with familial hypercholesterolemia showed no significant difference in LDL cholesterol (MD 0.02 mmol/l; 95% CI -0.06 to 0.11; P=0.60) compared to offspring of affected fathers.
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