Key result
taVNS reduces maximum exercise heart rate by ~4 bpm vs no stimulation in healthy volunteers.
Why the study?
Data on the effects of transcutaneous auricular vagus nerve stimulation on physiological function during exercise are lacking.
Does transcutaneous auricular vagus nerve stimulation (taVNS) alter hemodynamics and autonomic function during exercise stress tests in healthy volunteers?
Comparison
Exercise stress tests with vs without taVNS
Design
Randomized crossover trial
Follow-up
1 minute after exercise
Authors
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May inform autonomic modulation during exercise; extends taVNS effects to stress testing but needs patient trials.
RCT (n=15)
Randomized crossover
Does transcutaneous auricular vagus nerve stimulation (taVNS) alter hemodynamics and autonomic function during exercise stress tests in healthy volunteers?
Absolute Event Rate: 132% vs 136%
p-value: p=<0.001
Transcutaneous auricular vagus nerve stimulation reduces heart rate and induces parasympathetic dominance during exercise stress tests in healthy volunteers, suggesting potential utility in modulating autonomic tone.
Yoshida et al. (2025) conducted an RCT in Healthy (n=15). Transcutaneous auricular vagus nerve stimulation (taVNS) vs. Without taVNS was evaluated on Heart rate at maximum exercise (p=<0.001). Transcutaneous auricular vagus nerve stimulation significantly reduced heart rate at maximum exercise compared to no stimulation (132.0 vs 136.0; P<0.001) in healthy volunteers.