Key result
Calcium and sympathomimetic amines prolong survival ~3x in rats with verapamil-induced cardiovascular toxicity.
Why the study?
The acute cardiovascular toxicity of verapamil and effective antidotal treatments were investigated to identify agents that improve survival and cardiac function.
Do calcium or sympathomimetic amines improve survival time and cardiovascular hemodynamics in rats with acute verapamil toxicity?
Population
Rats anaesthetized with pentobarbital and ventilated artificially infused with 0.15 mg/kg/min verapamil
Design
Preclinical experimental study
Authors
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Hypothesis-generating for antidotes in verapamil toxicity; leaves open human translation pending clinical trials.
Do calcium or sympathomimetic amines improve survival time and cardiovascular hemodynamics in rats with acute verapamil toxicity?
Calcium and sympathomimetic amines are potent antidotes against acute cardiovascular toxicity of verapamil in a rat model, with sympathomimetics being superior for improving pacemaker activity and AV-conduction.
O. Strubelt (1984) studied Acute cardiovascular toxicity of verapamil. Calcium chloride, epinephrine, isoprenaline, orciprenaline, prenalterol, or plasma expander vs. Without antidotal treatment was evaluated on Survival time. Calcium and sympathomimetic amines more than trebled the survival time of rats with verapamil-induced cardiovascular toxicity compared to 51.1+/-7.1 minutes without treatment.
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