Key result
Strong immunosuppressive therapy linked to fatal purulent pericarditis from Candida and Acinetobacter in a dog.
Why the study?
Purulent pericarditis as a secondary disease in a dog treated with immune-suppressing drugs for immune-mediated hemolytic anemia was reported.
Case Report (n=1)
No
This case highlights the risk of fatal purulent pericarditis and cardiac tamponade as a secondary complication of immunosuppressive therapy in dogs with IMHA.
Raises caution for opportunistic pericarditis in heavily immunosuppressed canine IMHA; hypothesis-generating for prophylaxis strategies.
A 5-year-old castrated mongrel dog was brought to our hospital with anorexia and vomiting. Laboratory testing revealed immune-mediated hemolytic anemia (IMHA), and so treatment was initiated with multiple immune-suppressing drugs, achieving partial remission from IMHA. However, cardiac tamponade due to purulent pericarditis was identified as a secondary disease. Culture of pericardial fluid yielded numerous Candida albicans and multidrug-resistant Acinetobacter sp. Pericardiocentesis was performed, and the condition of the dog improved. However, the dog died the next day.
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Mohri et al. (2009) conducted a case report in Purulent pericarditis and immune-mediated hemolytic anemia (n=1). Immune-suppressing drugs was evaluated on Clinical outcome. A 5-year-old dog developed fatal purulent pericarditis associated with Candida albicans and Acinetobacter sp. following strong immunosuppressive multi-drug therapy for immune-mediated hemolytic anemia.
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