Key result
Extensive screening of Indian cattle for autosomal recessive disorders is necessary to prevent economic losses.
Why the study?
The prevalence and economic impact of autosomal recessive genetic disorders in Indian Holstein and crossbred cattle have increased, necessitating screening and control measures.
Screening for specific autosomal recessive disorders in Indian Holstein cattle is crucial to identify carriers and prevent economic losses in organized farms.
May support screening consideration in Indian Holstein herds; leaves open prevalence estimates and implementation feasibility.
Genetic diseases have always been present in the animal population but their significance has increased in recent decades. In some breeds, the occurrence of inherited anomalies has become frequent and economically important. Some of autosomal recessive disorders are Holstein specific. The present review article describes prevalence of the most important autosomal recessive disorders in Holstein and its crossbreds as compared to their occurrence worldwide. Mainly five disorders namely, bovine leukocyte adhesion deficiency (BLAD), deficiency of uridine monophosphate synthase (DUMPS), bovine citrullinaemia, complex vertebral malformation (CVM) and factor XI (FXI) deficiency syndrome, are being screened in Indian Holstein and its crossbred cattle with the major objective to reduce the incidence of genetic disorders in cattle population and reduce the economic losses to the organized farms. Detection of heterozygote carriers enables their selection, and therefore, the control and prevention of the spread of recessive diseases in the population.
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Kumar et al. (2015) conducted a review in Autosomal recessive genetic disorders. Autosomal recessive genetic mutations (BLAD, DUMPS, CVM, Citrullinaemia, FXI deficiency) vs. Non-carriers (wild-type) was evaluated on Prevalence and clinical impact of genetic disorders. Autosomal recessive genetic disorders are present in Holstein and crossbred cattle populations, necessitating extensive screening programs in India to identify carriers and prevent economic losses.
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