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Interleukin 6 (IL-6) is a multifunctional cytokine that acts on immune response, hematopoiesis, acute phase reactions and the nervous system1*.Thus, IL-6 plays one of the central regulatory roles in host defense mechanisms.However, it has been demonstrated that IL-6 produced by tumor cells causes cancer cachexia, and also stimulates the proliferation of tumor cells in an autocrine/paracrine manner2~5).Therefore, it may be possible that the inhibition ofIL-6 activity relieves cancer cachexia and suppress the growth of IL-6 dependent tumor cells.
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Takamatsu et al. (1997) studied this question.
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