Key result
Overt hypothyroidism is linked to substantially higher microalbuminuria odds versus other thyroid dysfunctions.
Why the study?
Thyroid dysfunction and microalbuminuria are associated with endothelial dysfunction, and establishing their relationship may help prevent related diseases with endothelial pathology.
Cross-Sectional (n=100)
No
Overt hypothyroidism is a strong predictor of microalbuminuria, highlighting a potential link between thyroid dysfunction and endothelial dysfunction.
Supports microalbuminuria evaluation in overt hypothyroidism; hypothesis-generating pending prospective confirmation.
Background: In India, 42 million people suffer from various kinds of thyroid disorders.Thyroid dysfunction and microalbuminuria are associated with endothelial dysfunction.Thus establishing a relationship between the two can play a significant role in prevention of endothelial dysfunction and hence modify diseases like obesity hypertension, diabetes, chronic kidney disease, cardiovascular disease which also have endothelial dysfunction as their basic pathology.Aim: To study the prevalence of microalbuminuria in patients with thyroid dysfunction.Materials & Methods: A cross-sectional study done among 100 newly diagnosed thyroid dysfunction patients who are screened for the presence of microalbuminuria along with lipid profile, fasting and post prandial blood sugar along with clinical history.The data collected is analyzed with SPSS version 23.Results: The prevalence of microalbuminuria in patients with thyroid dysfunction is found to be 43%.In univariate analysis, subjects with subclinical hypothyroidism had 1.08 to 5.63 times higher odds of having microalbuminuria compared to other study subjects and subjects with overt hypothyroidism had 5.03 to 40.9 times higher odds of having microalbuminuria compared to other study subjects both with a significant p value of 0.01.Conclusion: Overt Hypothyroidism is a strong and significant predictor of microalbuminuria compared to subclinical hypothyroidism.Also an inverse relationship between the FT3 and FT4 levels with microalbuminuria is noted.
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Sowmya Sridharan (2017) conducted a cross-sectional in Thyroid dysfunction (n=100). Overt hypothyroidism vs. Other thyroid dysfunctions was evaluated on Microalbuminuria (95% CI 5.03-40.9, p=0.01). Overt hypothyroidism was a strong predictor of microalbuminuria, associated with 5.03 to 40.9 times higher odds compared to other thyroid dysfunctions.
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