Key result
Microalbuminuria in ~28% of non-diabetic MI patients is linked to higher TIMI scores and multi-vessel disease.
Why the study?
Microalbuminuria acts as a marker for endothelial cell destruction and is associated with atherosclerosis in non-diabetic patients with myocardial infarction, but its prevalence was not well characterized.
Is microalbuminuria associated with myocardial infarction severity and coronary vessel involvement in non-diabetic patients?
Cross-Sectional (n=80)
No
Is microalbuminuria associated with myocardial infarction severity and coronary vessel involvement in non-diabetic patients?
Microalbuminuria is present in over a quarter of non-diabetic patients with myocardial infarction and correlates significantly with TIMI risk score and coronary vessel involvement.
Background: Urinary albumin excretion between 20 to 200 mg per litre is defined as microalbuminuria (MAU). MAU acts as a marker for endothelial cell destruction and is associated with atherosclerosis in both diabetics and non-diabetics. This study aimed to assess the MAU prevalence in nondiabetic patients with myocardial infarction.Methods: A cross-sectional study was conducted at tertiary care hospital. Among non-diabetic patients with myocardial infarction. The study was conducted from October 2019 to March 2020. All patients were subjected to complete physical examination, electrocardiography (ECG) and echocardiography. Quantitative determination of MAU was done in a urine sample. Diagnostic coronary angiogram was performed for all patients. Appropriated statistical tests were applied.Results: Among 80 study participants, 73.75% were men, and 26.25% were women. Smoking habit was present among 60%, and 56.25% were hypertensive. The prevalence of microalbuminuria was 27.5%. A statistically significant difference was seen between TIMI scoring and presence of MAU (p<0.001). The difference in vessels type between the microalbuminuria status was found to be significant (p=0.005).Conclusions: Evidence from this study shows that the presence of MAU had a strong association between myocardial infarction and its application as a risk factor of cardiovascular diseases in general non-diabetic population proves practical.
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Thanikachalam et al. (2020) conducted a cross-sectional in Non-diabetic myocardial infarction (n=80). Microalbuminuria vs. Absence of microalbuminuria was evaluated on Prevalence of microalbuminuria. Among non-diabetic patients with myocardial infarction, the prevalence of microalbuminuria was 27.5% and was significantly associated with higher TIMI scores (p<0.001) and multi-vessel disease (p=0.005).
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