Updated Prevalence of mcr -Like Genes among Escherichia coli and Klebsiella pneumoniae in the SENTRY Program and Characterization of mcr-1.11 Variant

Lalitagauri M. Deshpande; Cory Hubler; Andrew P. Davis; Mariana Castanheira

doi:10.1128/aac.02450-18

January 28, 2019Antimicrobial Agents and ChemotherapyOpen Access

Updated Prevalence of mcr -Like Genes among Escherichia coli and Klebsiella pneumoniae in the SENTRY Program and Characterization of mcr-1.11 Variant

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Key Points

To determine the prevalence of plasmid-borne mcr-like genes among clinical isolates of Escherichia coli and Klebsiella pneumoniae and characterize the novel mcr-1.11 variant.
Screened international clinical isolates of Escherichia coli and Klebsiella pneumoniae collected via the SENTRY Antimicrobial Surveillance Program for polymyxin resistance.
Performed molecular screening, whole-genome sequencing, and biochemical testing to identify mcr variants and evaluate resistance phenotypes.
Demonstrated that mcr-like genes occur at low baseline frequencies among clinical Escherichia coli and Klebsiella pneumoniae isolates.
Identified and characterized the mcr-1.11 variant, confirming its role in mediating reduced susceptibility to polymyxin antibiotics.

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Implication

Surveillance study reveals low frequency of mcr-like genes in Escherichia coli and Klebsiella pneumoniae, highlighting novel colistin resistance mechanisms.

Abstract

Increased prevalence of infections caused by Gram-negative pathogens that are multidrug resistant has prompted the reconsideration of polymyxins as therapeutic options.…

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Deshpande et al. (2019) studied this question.

synapsesocial.com/papers/6aaca64a29466d65a41ef295 https://doi.org/10.1128/aac.02450-18

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Updated Prevalence of mcr -Like Genes among Escherichia coli and Klebsiella pneumoniae in the SENTRY Program and Characterization of mcr-1.11 Variant

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Updated Prevalence of mcr -Like Genes among Escherichia coli and Klebsiella pneumoniae in the SENTRY Program and Characterization of mcr-1.11 Variant

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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