Key result
Ribavirin treatment linked to full neurological recovery at 6 months in severe Hepatitis E-induced myositis.
Why the study?
Hepatitis E virus is endemic in some regions but rarely recognized by neurologists in Western countries despite neurological manifestations including myositis.
Case Report (n=1)
Ribavirin treatment may be effective for severe HEV infection presenting with severe myositis, leading to rapid neurological recovery.
Answers are grounded in this paper and cite their sources.
HEV myositis should be considered in acute tetraparesis with hepatitis; leaves open prevalence and causality in larger cohorts.
INTRODUCTION: Hepatitis E virus (HEV) is endemic in Asian and African countries but is rarely reported in Western countries. Although there are some prominent neurological manifestations, HEV is rarely recognized by neurologists. METHODS: This is a case report of myositis induced by HEV. RESULTS: We report the life-threatening case of a 57-year-old man with flaccid tetraparesis due to myositis, acute hepatitis, and renal failure caused by HEV infection. Muscle biopsy revealed scattered myofiber necrosis with a diffuse, mild lymphomonocytic infiltrate in the endomysium and perimysium. Because the patient suffered from an acute HEV infection with a rapidly progressive course of severe myopathy, we started ribavirin treatment. He recovered partially within 3 weeks and recovered fully within 6 months. CONCLUSION: This case highlights a neurological manifestation of endemic HEV infection with severe myositis in a patient with alcoholic chronic liver disease. Ribavirin treatment is effective in severe HEV infection and may also lead to rapid neurological recovery.
No takes yet. Share an insight, caveat, or question.
Mengel et al. (2015) conducted a case report in Hepatitis E-induced severe myositis (n=1). Ribavirin was evaluated on Neurological recovery. Ribavirin treatment led to partial recovery within 3 weeks and full neurological recovery within 6 months in a patient with severe myositis induced by acute Hepatitis E infection.
Synapse has enriched 10 related papers. Consider them for comparative context: