What is the clinical evidence from this study?

Study design: Cohort. Population: Permanent pacemakers or implantable-cardioverter-defibrillators (n=104). Intervention: Right ventricular pacing in VVI mode vs. Non-VVI mode (AAI or DDD). Primary outcome: new onset atrial fibrillation (p=<0.0001).

What does this research mean for the field?

Right ventricular pacing in VVI mode is associated with a significantly higher incidence of new-onset atrial fibrillation, left atrial enlargement, and mitral regurgitation compared to non-VVI pacing modes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2014Medical Science MonitorOpen Access

Incidence of new onset atrial fibrillation in patients with permanent pacemakers and the relation to the pacing mode

Q: What are the key findings of this study?

Right ventricular pacing in VVI mode was associated with a significantly higher incidence of new onset atrial fibrillation compared to non-VVI pacing modes (85.7% vs 37.4%; P<0.0001).

Q: What does this research mean for the field?

Right ventricular pacing in VVI mode is associated with a significantly higher incidence of new-onset atrial fibrillation, left atrial enlargement, and mitral regurgitation compared to non-VVI pacing modes. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

VVI-mode RVP linked to ~129% greater incidence of new-onset AF than non-VVI pacing.

P<0.0001
n=104

Why the study?

Atrial fibrillation is common in patients with permanent pacemakers, but the incidence related to different pacing modes was unclear.

Does VVI pacing mode increase the incidence of new-onset atrial fibrillation compared to non-VVI pacing in patients with permanent pacemakers?

Comparison

Right ventricular pacing (VVI mode) vs non-VVI pacing mode (AAI or DDD)

Design

Cohort study

Follow-up

Mean 6 years and 3 months

Discussion

Member takes

Overview

May warrant avoiding VVI mode when feasible to lower AF risk; hypothesis-generating and requires prospective confirmation before practice change.

Study Design

Type

Cohort (n=104)

Structured PICO

Does VVI pacing mode increase the incidence of new-onset atrial fibrillation compared to non-VVI pacing in patients with permanent pacemakers?

Population

104 patients with permanent pacemakers or implantable-cardioverter-defibrillators, mean age 68 years, followed for a mean of 6 years and 3 months.

Exposure

Right ventricular pacing (VVI mode)

Comparator

Non-VVI pacing mode (AAI or DDD)

Outcome

Incidence of new-onset atrial fibrillationhard clinical

Main Result

Absolute Event Rate: 85.7% vs 37.4%

p-value: p=<0.0001

Right ventricular pacing in VVI mode is associated with a significantly higher incidence of new-onset atrial fibrillation compared to non-VVI pacing modes.

Cite This Study

A 2014 study conducted a cohort in Permanent pacemakers or implantable-cardioverter-defibrillators (n=104). Right ventricular pacing in VVI mode vs. Non-VVI mode (AAI or DDD) was evaluated on new onset atrial fibrillation (p=<0.0001). Right ventricular pacing in VVI mode was associated with a significantly higher incidence of new onset atrial fibrillation compared to non-VVI pacing modes (85.7% vs 37.4%; P<0.0001).

synapsesocial.com/papers/6aacaa6afedf63ea06ca0e59 https://doi.org/10.12659/msm.890052

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January 1, 2014Medical Science MonitorOpen Access

Incidence of new onset atrial fibrillation in patients with permanent pacemakers and the relation to the pacing mode

View Full Paper

Ask AI

Bookmark

Key result

VVI-mode RVP linked to ~129% greater incidence of new-onset AF than non-VVI pacing.

P<0.0001
n=104

Why the study?

Atrial fibrillation is common in patients with permanent pacemakers, but the incidence related to different pacing modes was unclear.

Does VVI pacing mode increase the incidence of new-onset atrial fibrillation compared to non-VVI pacing in patients with permanent pacemakers?

Comparison

Right ventricular pacing (VVI mode) vs non-VVI pacing mode (AAI or DDD)

Design

Cohort study

Follow-up

Mean 6 years and 3 months

Discussion

Member takes

Overview

May warrant avoiding VVI mode when feasible to lower AF risk; hypothesis-generating and requires prospective confirmation before practice change.

Study Design

Type

Cohort (n=104)

Structured PICO

Does VVI pacing mode increase the incidence of new-onset atrial fibrillation compared to non-VVI pacing in patients with permanent pacemakers?

Population

104 patients with permanent pacemakers or implantable-cardioverter-defibrillators, mean age 68 years, followed for a mean of 6 years and 3 months.

Exposure

Right ventricular pacing (VVI mode)

Comparator

Non-VVI pacing mode (AAI or DDD)

Outcome

Incidence of new-onset atrial fibrillationhard clinical

Main Result

Absolute Event Rate: 85.7% vs 37.4%

p-value: p=<0.0001

Right ventricular pacing in VVI mode is associated with a significantly higher incidence of new-onset atrial fibrillation compared to non-VVI pacing modes.

Cite This Study

synapsesocial.com/papers/6aacaa6afedf63ea06ca0e59 https://doi.org/10.12659/msm.890052

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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