What question did this study set out to answer?

To determine whether temporal changes in prostate cancer diagnosis and treatment over a 20-year span modified the association between obesity and disease progression following radical retropubic prostatectomy.

April 15, 2005Clinical Cancer Research

Stronger Association between Obesity and Biochemical Progression after Radical Prostatectomy among Men Treated in the Last 10 Years

View Full Paper

Ask AI

Bookmark

To determine whether temporal changes in prostate cancer diagnosis and treatment over a 20-year span modified the association between obesity and disease progression following radical retropubic prostatectomy.
Evaluated N=2,832 men undergoing anatomic radical retropubic prostatectomy by a single surgeon between 1985 and 2004.
Assessed obesity (body mass index ≥30 kg/m²) in relation to tumor stage and grade using logistic regression, and biochemical progression using multivariable Cox proportional hazards regression.
The positive association between obesity and biochemical progression was strongest among men treated since 1995 (relative risk, 1.90; 95% CI, 1.09–3.30; P = 0.02).
Multivariable analysis demonstrated an increasing strength of association over time between obesity and high-grade disease, whereas the association with positive surgical margins decreased.
The association between obesity and extraprostatic extension varied across eras, reaching statistical significance only in men treated since 2000.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Cohort study reveals a strengthening link between obesity and biochemical progression in men undergoing radical prostatectomy, indicating evolving clinical patterns.

Cite This Study

Freedland et al. (2005) studied this question.

synapsesocial.com/papers/6aacad31c7e7115b44b0dcb3 https://doi.org/10.1158/1078-0432.ccr-04-2257

View Full Paper

Ask AI

Bookmark

Implication

Cohort study reveals a strengthening link between obesity and biochemical progression in men undergoing radical prostatectomy, indicating evolving clinical patterns.

Stronger Association between Obesity and Biochemical Progression after Radical Prostatectomy among Men Treated in the Last 10 Years

Key Points

Discussion

Implication

Cite This Study

Stronger Association between Obesity and Biochemical Progression after Radical Prostatectomy among Men Treated in the Last 10 Years

Key Points

Discussion

Implication

Cite This Study

Also Consider

Also Consider