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A one‐way mixed lymphocyte culture (MLC) across the major H‐2 barrier produces effector cells which lyse allogeneic target cells in vitro. The MLC‐antigen reactive cells are electrokinetically high mobility lymphocytes, and do not need the co‐operation of low mobility lymphocytes in the initiation of the response. The MLC‐effector cells, harvested on the 6th culture day, are all high mobility cells. They are also sensitive to anti Θ serum plus complement. The results show that T cells, independent of B cells, can both respond to allogeneic cells and lyse them.
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Andersson et al. (1973) studied this question.
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