Mechanism and Kinetics of the Acid-Catalyzed Dehydration of 1- and 2-Propanol in Hot Compressed Liquid Water

Only propene and 1-propanol are observed as products of the acid-catalyzed dehydration of 2-propanol in compressed liquid water after 100 s or less at 320 °C. Likewise, only propene, 2-propanol, and traces of n -propyl ether are observed as products of the acid-catalyzed dehydration of 1-propanol under the same conditions. Kinetic analyses of the experimental data indicate that propene is formed from 1-propanol by an acid-catalyzed E2 mechanism that involves only protonated 1-propanol as an intermediate. Byproduct n -propyl ether is formed by an Ad E 3 mechanism involving propene, 1-propanol, and acid. The formation of propene from 2-propanol is kinetically consistent with both an acid-catalyzed E2 mechanism and an acid-catalyzed E1 mechanism (that involves the bare i -propyl cation in addition to protonated 2-propanol as intermediates in the dehydration chemistry). Thus, our kinetic analysis does not enable us to discriminate between the two mechanisms for 2-propanol dehydration. On the other hand, results of the kinetic analysis point to the important role of the undetected product i -propyl ether in the formation of propene from both 2-propanol and 1-propanol. This ether (which is not stable in hot liquid water) is formed by an Ad E 3 mechanism and decomposes via an uncatalyzed, unimolecular reaction. Experimental studies of the reactions of n -propyl ether and i -propyl ether are consistent with model predictions.