Key result
Bilateral adrenal hemorrhage can present as the initial manifestation of APS and SLE.
Why the study?
Bilateral adrenal hemorrhage is a rare cause of adrenal insufficiency and is infrequently associated with antiphospholipid syndrome, with limited case reports describing this presentation.
Case Report (n=1)
No
This case highlights the importance of screening for underlying autoimmune diseases like APS in patients presenting with bilateral adrenal hemorrhage and unexplained cardiac manifestations.
Bilateral adrenal hemorrhage warrants APS consideration in SLE patients with flank pain; extends sparse reports but leaves open questions on prevalence.
Background: bilateral adrenal hemorrhage can cause adrenal insufficiency. Antiphospholipid syndrome (APS) is considered a rare etiology of bilateral adrenal hemorrhage with a relatively small number of case reports. APS can be secondary to other autoimmune diseases such as SLE in which cardiac manifestations are common. Case presentation: a fifty-four-year-old male presents with left flank pain as a result of unilateral adrenal hemorrhage, a few days later, bilateral hemorrhage is documented in the presence of abnormal coagulation state and other laboratory clues. APS diagnosis was established. Coexisting chest pain accompanied by diffused ST elevation, long QT, slightly high troponin with a high pro-BNP, in addition to echo’s findings such abnormal regional wall abnormality and the absence of pericardial effusion made the case more interesting, differential diagnosis was proposed in accordance. Conclusion: bilateral hemorrhage in APS considered rare. Requiring a high index of clinical suspicion. Particularly when it is the initial manifestation of APS as in our case. Underlying autoimmune diseases should be screened actively, especially when other unexplained manifestations are presented.
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Lev et al. (2020) conducted a case report in Bilateral adrenal hemorrhage, Antiphospholipid syndrome, Systemic lupus erythematosus (n=1). Antiphospholipid syndrome was evaluated. Bilateral adrenal hemorrhage can be the initial manifestation of antiphospholipid syndrome and systemic lupus erythematosus, requiring a high index of clinical suspicion.
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