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BACKGROUND: This study was performed to delineate the relationship between plasminogen activator inhibitor type-1 (PAI-1) activity and PAI-1 protein to characterize the functional importance of elevated PAI-1 in diabetes. METHODS: PAI-1 activity (chromogenic substrate kinetic assay) and protein (enzyme-linked immunosorbent assay) were assayed in baseline central venous catheter-acquired samples from 170 patients with type 2 diabetes studied in the Troglitazone Atherosclerosis Regression Trial (TART). RESULTS: The data demonstrated that the ratio of PAI-1 activity to the concentration of PAI-1 protein is increased as a function of increasing concentrations of PAI-1 protein in blood. CONCLUSIONS: The results demonstrate that the ratio of PAI-1 activity to the concentration of PAI-1 protein is higher when the concentration of PAI-1 is elevated. The nonlinearity appears to depend on the fact that the rate of disappearance of PAI-1 activity in blood is a function of the concentration of PAI-1 protein.
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Sobel et al. (2002) studied this question.
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