Family study reveals normal clinical and haematological parameters in Haemoglobin J-Bangkok carriers, indicating a benign phenotype without detrimental interaction with alpha-thalassaemia.
SUMMARY A Thai family with haemoglobins A + J‐Bangkok in nine persons is described. This rare abnormal pigment had identical electrophoretic mobility to other haemoglobins J, but, as α2β256Asp, is not similar to any previously described haemoglobin. Carriers of this haemoglobin were clinically and haematologically normal except for the presence of 47.4–67.2 per cent Hb J. It was also possible to follow the increment of Hb J‐Bangkok from 16.15 per cent in the cord blood to 46 per cent at 2½ months and to 55.18 per cent at 1 year of age. One person is believed to harbour both an α‐thalassaemia and Hb J‐Bangkok genes without evidence of interaction.
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Pootrakul et al. (1967) studied this question.
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