Key result
Idiopathic HCM is linked to ~24% higher serum free carnitine levels versus normal subjects.
Why the study?
The clinical significance of serum carnitine concentrations in determining the severity of impaired myocardial fatty acid metabolism in idiopathic hypertrophic cardiomyopathy was unclear.
Do serum carnitine concentrations correlate with impaired myocardial fatty acid metabolism in patients with idiopathic hypertrophic cardiomyopathy?
Observational (n=56)
Do serum carnitine concentrations correlate with impaired myocardial fatty acid metabolism in patients with idiopathic hypertrophic cardiomyopathy?
Absolute Event Rate: 52.5% vs 42.3%
p-value: p=<0.0001
Serum carnitine concentrations are increased in idiopathic HCM and serve as a sensitive indicator of the severity of impaired myocardial fatty acid metabolism.
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May indicate impaired fatty acid metabolism in idiopathic HCM; hypothesis-generating and requires prospective validation before clinical use.
Nakamura et al. (1999) conducted an observational in Idiopathic hypertrophic cardiomyopathy (HCM) (n=56). Idiopathic hypertrophic cardiomyopathy vs. Normal subjects was evaluated on Serum free carnitine levels (nmol/ml) (p=<0.0001). Serum free carnitine levels were significantly higher in patients with idiopathic hypertrophic cardiomyopathy than in normal subjects (52.5 vs 42.3 nmol/ml; P<0.0001).
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