Key result
~41% of premenopausal women with ACS have angiographically normal coronaries, significantly higher than postmenopausal women.
Why the study?
Evaluation of coronary artery disease among premenopausal women has been neglected as it is considered rare, necessitating comparison of risk factor profiles in premenopausal and postmenopausal Indian women with ACS.
Does the risk factor profile and coronary disease pattern differ between premenopausal and postmenopausal Indian women presenting with acute coronary syndrome?
Observational (n=232)
No
Does the risk factor profile and coronary disease pattern differ between premenopausal and postmenopausal Indian women presenting with acute coronary syndrome?
Absolute Event Rate: 40.9% vs 22.29%
p-value: p=0.004
In Indian women presenting with acute coronary syndrome, premenopausal women are more likely to have nonatherosclerotic and nonobstructive coronary artery disease compared to postmenopausal women.
Introduction: More women die of cardiovascular diseases than from any other illness. Evaluation of coronary artery disease (CAD) among premenopausal women has been neglected, since it is been considered to be rare. The purpose of this study was to compare the risk factor profile for CAD in premenopausal and postmenopausal Indian women presenting with acute coronary syndrome. Materials and Methods: This retrospective study was carried out at the Department of Cardiology, in a tertiary care cardiac center in Trivandrum, Kerala, India. Clinical and risk factor data were collected by reviewing hospital records. Coronary angiograms were assessed by two independent cardiologists. Results: A total of 232 patients were included in the study, of which 66 were in the premenopausal group with mean age of (45.85 ± 4.25) years, and 166 in the postmenopausal group with mean age of (67.40 ± 6.40) years. The incidence of hypertension (31 [46.96%] vs. 133 [80.12%], P < 0.001) and diabetes mellitus (28 [42.42%] vs. 104 [62.65%], P < 0.005) was higher among the postmenopausal women. ST elevation myocardial infarction was significantly higher (5 [7.57%] vs. 31 [18.67%], P = 0.035) among postmenopausal women. Coronary angiography showed that the premenopausal women had higher incidence of angiographically normal coronaries (27 [40.90%] vs. 37 [22.29%], P = 0.004), whereas postmenopausal women had more atherosclerotic triple vessel disease (7 [10.60%] vs. 46 [27.71%], P = 0.005).Conclusions: The CAD in premenopausal women is mostly nonatherosclerotic and nonobstructive. The conventional risk factors do not play a significant role among this subset of population.
No takes yet. Share an insight, caveat, or question.
Soman et al. (2016) conducted an observational in Acute coronary syndrome (n=232). Premenopausal status vs. Postmenopausal status was evaluated on Angiographically normal coronaries (p=0.004). Premenopausal women with acute coronary syndrome had a higher incidence of angiographically normal coronaries compared to postmenopausal women (40.90% vs. 22.29%, P=0.004).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: