Key result
Elongating rigid stenosis increases flow ~25% in a mechanical model.
Why the study?
Hemodynamic characteristics and energy losses associated with different types of stenosis in peripheral blood vessels were not fully understood.
How do different types of stenosis (focal, elongated soft, elongated rigid) affect hemodynamics in a mechanical model of peripheral blood vessels?
How do different types of stenosis (focal, elongated soft, elongated rigid) affect hemodynamics in a mechanical model of peripheral blood vessels?
In an in vitro mechanical model, the critical stricture size and length of stenosis significantly impact flow and energy dissipation, with rigid stenoses having a larger critical stricture than soft stenoses.
Mechanical models indicate stenosis rigidity and length alter flow; leaves open translation to peripheral artery disease management.
Hemodynamic aspects of obliterative processes in peripheral blood vessels were studied on a mechanical model built of distensible tubing, with a fixed peripheral resistance, through which citrated blood was circulated by pulsatile flow. Hemodynamics of progressive focal stenosis, elongated soft stenosis, and elongated rigid stenosis were assessed. By the use of a hydrodynamic model and a series of in vitro experiments, we have measured the pressure and flow characteristics, and calculated the pressure and energy losses for the various stenotic sites. The critical stricture was found to be larger for a rigid stenosis than a soft stenosis. The length of the stenosis was also an important factor. Increasing the length of a rigid stenosis, for example, by 50 percent resulted in an increase of 25 percent in the flow through the stenosis. The energy dissipation was determined as a preferred indication for several parameters such as: pressure drop, pulsed flow, pulse rate, and the geometry and mechanical properties of the stenosis.
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Einav et al. (1992) studied Obliterative processes in peripheral blood vessels. Progressive focal, elongated soft, and elongated rigid stenosis was evaluated on Pressure and flow characteristics, pressure and energy losses. In a mechanical model, the critical stricture was larger for a rigid stenosis than a soft stenosis, and increasing rigid stenosis length by 50% resulted in a 25% increase in flow.
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