Key result
Age over 60 is linked to ~142% greater femoral artery stiffness versus men under 35.
Why the study?
Measurements of human femoral arterial wall properties noninvasively across different age groups were needed to understand arterial stiffness changes with aging.
Cross-Sectional
Transcutaneous ultrasonic measurement demonstrates that human femoral arteries become stiffer with age, though with significant individual variation.
Age-related femoral stiffening observed in men; leaves open its contribution to cardiovascular risk and need for longitudinal validation.
Measurements of human femoral arterial wall properties have been obtained transcutaneously in a group of males who were clinically free of arteriosclerosis obliterans. The patients were divided into three groups according to age: under 35, 35-60, and over 60 years. Diameter and changes in diameter were measured using an ultrasonic echo-tracking system. Arterial pulse pressure was determined by the auscultatory method. The results suggest that arteries become stiffer with age. The pressure-strain elastic modulus (Ep) varied from 2.6 ± 0.3 sem x 10 6 dynes/cm 2 in the young group to 6.3 ± 1.0 sem x 10 6 dynes/cm 2 in the old group. These values are similar to those reported by other investigators using invasive and in vitro technics. Although statistical comparisons indicate a significant difference between groups, there was considerable variation within the groups. Not infrequently, values for Ep obtained from individuals in the oldest group fell well within the range of the values obtained in the young group.
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Mozersky et al. (1972) conducted a cross-sectional in Free of arteriosclerosis obliterans. Age vs. Younger age was evaluated on Pressure-strain elastic modulus (Ep). Femoral artery stiffness increased with age, with the pressure-strain elastic modulus rising from 2.6 ± 0.3 x 10^6 dynes/cm^2 in men under 35 to 6.3 ± 1.0 x 10^6 dynes/cm^2 in men over 60.
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