Key result
XGBoost model predicts 48-hour emergency delivery in early-onset preeclampsia with ~0.91 AUROC.
Why the study?
Early-onset preeclampsia poses significant risks for maternal and fetal outcomes, particularly when emergency delivery is required, necessitating improved prediction methods.
Cohort (n=648)
No
Machine learning models, particularly XGBoost, can accurately predict the need for emergency delivery within 48 hours in early-onset preeclampsia using routine clinical and laboratory features.
Answers are grounded in this paper and cite their sources.
May support risk stratification for emergency delivery in early-onset preeclampsia; leaves open prospective validation before clinical use.
BACKGROUND: Early-onset preeclampsia (PE) poses significant risks for maternal and fetal outcomes, particularly when emergency delivery is required. This study aimed to develop machine learning models to predict emergency delivery within 48 h of PE diagnosis, facilitating timely clinical interventions. METHODS: We analyzed a retrospective cohort of 648 singleton pregnancies diagnosed with PE at Fujian Maternal and Child Health Hospital from 2014 to 2024, with gestational ages ranging from 28 to 34 weeks. Patients were stratified into emergency delivery (≤ 48 h post-diagnosis, n = 174) and non-emergency groups (n = 474). Feature selection was performed via univariate analysis, collinearity testing, and logistic regression, yielding 16 predictors. Eight machine learning models (logistic regression, naïve Bayes, XGBoost, LightGBM, SVM, GBDT, MLP, elastic net) were trained and evaluated for discriminative power and calibration. SHAP analysis was employed to interpret model predictions. RESULTS: XGBoost demonstrated superior performance (testing AUROC: 0.908) with excellent calibration, while GBDT achieved high AUROC (0.931) but poorer calibration. SHAP analysis identified CRP, D-dimer, and hypoproteinemia as the most influential predictors. CONCLUSIONS: Machine learning models effectively predict emergency delivery in early-onset PE using clinically interpretable features. Integration into obstetric practice may enhance risk stratification, though prospective validation is warranted.
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Xu et al. (2025) conducted a cohort in Early-onset preeclampsia (n=648). XGBoost machine learning model vs. Other machine learning models was evaluated on Prediction of emergency delivery (≤ 48 h post-diagnosis) (AUROC 0.908). An XGBoost machine learning model effectively predicted emergency delivery within 48 hours in early-onset preeclampsia with a testing AUROC of 0.908, identifying CRP, D-dimer, and hypoproteinemia as key predictors.
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