Key result
Noninvasive tests poorly predict significant CAD affecting 43% of asymptomatic T1D islet transplant candidates.
Why the study?
The prevalence of asymptomatic coronary artery disease in nonuremic type 1 diabetic patients is unknown, and optimal cardiac risk stratification in this population is needed.
Population
60 consecutive nonuremic type 1 diabetic islet transplant candidates, average age 46 years, 23 men, 47% ever smokers
Comparison
Coronary angiography vs electrocardiographic stress testing and myocardial perfusion imaging
Design
Prospective cohort study
Authors
Loading...
Negative noninvasive tests should not reassure in asymptomatic T1D islet candidates; leaves open optimal screening strategies.
Cohort (n=60)
Asymptomatic coronary artery disease is highly prevalent in nonuremic type 1 diabetic islet transplant candidates, and standard noninvasive tests (EST and MPI) have poor sensitivity for its detection.
Senior et al. (2005) conducted a cohort in Type 1 diabetes (n=60). Nonuremic type 1 diabetes was evaluated on Coronary artery disease (stenoses >50% on angiography) in asymptomatic subjects. Among asymptomatic, nonuremic type 1 diabetic islet transplant candidates, 43% had significant coronary artery disease on angiography, which was poorly predicted by noninvasive testing.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: