Key result
Oral propranolol drives complete regression of neonatal cardiac haemangiomas in 2 patients.
Why the study?
Cardiac haemangiomas are extremely rare tumours with equivocal surgical outcomes and oral propranolol treatment has not been previously tried for cardiac location.
Does oral propranolol lead to regression of cardiac haemangiomas in neonates?
Case Report (n=2)
Does oral propranolol lead to regression of cardiac haemangiomas in neonates?
Oral propranolol successfully treated rare neonatal cardiac haemangiomas, resulting in complete tumor regression within the first year of life.
Answers are grounded in this paper and cite their sources.
May support propranolol in neonatal cardiac haemangiomas; hypothesis-generating from two cases, prospective data needed.
BACKGROUND: Cardiac haemangiomas are extremely rare tumours with equivocal surgical outcomes. Haemangiomas appearing on other sites of the body have been successfully treated with oral propranolol. To the best of our knowledge, such treatment has not been tried to date for cardiac location of haemangiomas. CASE SUMMARY: We report two cases of neonatal cardiac haemangiomas, and we describe their presentation and characteristics, as well as how these were successfully treated with oral propranolol, with complete regression of the tumours within the 1st year of life. DISCUSSION: Despite the rarity of cardiac haemangiomas, their presentation and complications could be dramatic with side-effects spanning from intracardiac space occupying phenomena to Kasabach-Merritt syndrome. Propranolol therapy, having been established for long now in the treatment of skin haemangiomas, should also be considered in cases of cardiac haemangiomas, particularly in the neonatal and infantile population.
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Polymerou et al. (2019) conducted a case report in Neonatal cardiac haemangiomas (n=2). Oral propranolol was evaluated on Complete regression of the tumours. Oral propranolol successfully treated neonatal cardiac haemangiomas, resulting in complete regression of the tumours within the first year of life in two patients.
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