Key result
G2P[4] constitutes ~41% of rotavirus-positive samples as the most common strain in mid-western Turkey.
Why the study?
Vaccines against rotaviruses may show varying efficiencies against different genotypes, and routine vaccination might lead to selection and immune escape of wild-type strains, necessitating strain surveillance before and during vaccine introduction.
What is the baseline prevalence of rotavirus genotypes in mid-western Turkey?
Cross-Sectional (n=41)
What is the baseline prevalence of rotavirus genotypes in mid-western Turkey?
The study establishes a baseline of rotavirus genotype prevalence in mid-western Turkey prior to or during vaccine introduction, with G2P[4] being the most common strain.
Provides baseline rotavirus genotype data in mid-western Turkey; leaves open need for post-vaccine surveillance.
Vaccines against rotaviruses are now available in numerous countries, including Turkey. As the vaccines may show various efficiencies against different type specificities and routine vaccination in infants might result in selection and immune escape of wild-type rotavirus strains, strain surveillance has been initiated before and during the vaccine introduction. We aimed to provide corresponding information on local strain prevalence in Anatolia, mid-western Turkey during the introduction of rotavirus vaccines. Stool samples positive for group A rotavirus by commercial enzyme immunoassay were subjected to reverse transcription-polymerase chain reaction based genotyping of the outer capsid antigens, VP7 and VP4, determining G and P type specificities respectively. Among 36 fully and 5 partially typeable strains we detected genotype G1, G2, and G9 VP7 specificities and genotype P[4], P[6] and P[8] VP4 specificities in 5 individual and 4 mixed combinations. The most common strain was G2P[4] (n=17), followed by G9P[8] (n=9). Other strains were G1P[8] (n=2), G2P[8] (n=2), G1+2P[8] (n=2), G9P[4] (n=1), G2+9P[8] (n=1), G4+9P[6] (n=1), and G2P[4+8] (n=1). Partially typed strains included 2 G1P[NT] and 3 G2P[NT] strains. Our data may help determine a baseline of the rotavirus genotype prevalence in Turkey and see if changes in the incidence of individual strains will be observed after routine use of vaccine.
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Altındiş et al. (2009) conducted a cross-sectional in Rotavirus infection (n=41). Rotavirus strain genotyping was evaluated on Rotavirus genotype prevalence (G and P type specificities). Among 41 rotavirus-positive stool samples in mid-western Turkey, the most common strain was G2P[4] (n=17), followed by G9P[8] (n=9).
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