Key result
WFIKKN1 and WFIKKN2 potently antagonize myostatin and GDF11 via their follistatin and NTR domains.
Why the study?
The biological functions and interactions of the multidomain proteins WFIKKN1 and WFIKKN2 with growth factors myostatin and GDF11 require further elucidation.
WFIKKN1 and WFIKKN2 are multidomain proteins that function as potent antagonists of myostatin and GDF11.
WFIKKN1/2 may guide myostatin pathway modulation in muscle or cardiac disease; leaves open therapeutic validation in clinical models.
WFIKKN1 and WFIKKN2 are two closely related multidomain proteins consisting of a WAP (whey acidic protein)-, a follistatin-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains and an NTR domain (netrin domain). Recent experiments have shown that both WFIKKN1 and WFIKKN2 bind myostatin and GDF11 (growth and differentiation factor 11) with high affinity and are potent antagonists of these growth factors. Structure-function studies on WFIKKN proteins have revealed that their interactions with GDF8 and GDF11 are mediated primarily by the follistatin and NTR domains.
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Kondás et al. (2011) reported a review. WFIKKN1 and WFIKKN2 was evaluated. WFIKKN1 and WFIKKN2 bind myostatin and GDF11 with high affinity and act as potent antagonists, with interactions mediated primarily by their follistatin and NTR domains.
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