Key result
Mitochondrial OXPHOS genes face positive selection in low-performance lineages and purifying selection in high-performance taxa.
Why the study?
Natural selection on mitochondrial oxidative phosphorylation genes in fishes with extreme aerobic performance has been studied mainly for directional selection on specific branches, lacking a broader evolutionary context.
Population
Multiple lineages of fishes with extreme high and low aerobic performance
Comparison
High aerobic performance taxa vs low aerobic performance taxa
Design
Evolutionary analysis of natural selection patterns on mitochondrial OXPHOS genes
Authors
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Highlights lineage-specific mitochondrial adaptation; leaves open relevance to human cardiovascular performance or disease.
Zhang et al. (2015) studied Aerobic performance in fishes. Aerobic performance vs. Different performance levels was evaluated on Patterns of natural selection on mitochondrial OXPHOS genes. Positive selection on mitochondrial OXPHOS genes is strongest on lineages containing low performance taxa, while purifying selection predominates within high performance lineages.
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