Cardiac Disease in Costello Syndrome

Experience and Reason| April 01 1998 Cardiac Disease in Costello Syndrome Ernest S. Siwik, MD; Ernest S. Siwik, MD Search for other works by this author on: This Site PubMed Google Scholar Kenneth G. Zahka, MD; Kenneth G. Zahka, MD Search for other works by this author on: This Site PubMed Google Scholar Georgia L. Wiesner, MD; Georgia L. Wiesner, MD Search for other works by this author on: This Site PubMed Google Scholar Chanin Limwongse, MD Chanin Limwongse, MD Search for other works by this author on: This Site PubMed Google Scholar Reprint requests to (E.S.S.) Division of Pediatric Cardiology, Rainbow Babies and Children's Hospital, 11100 Euclid Ave, Cleveland, OH 44106-5038. Pediatrics (1998) 101 (4): 706–708. https://doi.org/10.1542/peds.101.4.706 Article history Received: April 22 1997 Accepted: September 11 1997 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ernest S. Siwik, Kenneth G. Zahka, Georgia L. Wiesner, Chanin Limwongse; Cardiac Disease in Costello Syndrome. Pediatrics April 1998; 101 (4): 706–708. 10.1542/peds.101.4.706 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search toolbar search search input Search input auto suggest filter your search All PublicationsAll JournalsPediatricsHospital PediatricsPediatrics In ReviewNeoReviewsAAP Grand RoundsAAP NewsAll AAP Sites Search Advanced Search Topics: costello syndrome, heart diseases In 1977, Costello1 described 2 patients with a new multiple congenital anomalies/mental retardation syndrome. Recently, additional reports of Costello syndrome have been published, bringing the number of patients described to near 30.2-18 Features of the syndrome include postnatal growth deficiency, mental retardation, cutis laxa, characteristic facies, papillomas, and various cardiac abnormalities.18 The syndrome is thought to be a result of sporadic autosomal dominant mutations, although the gene involved is unknown.19 Articles discussing Costello syndrome have consisted of single case reports or small series confined primarily to the genetics literature. This fact, coupled with the uncommon nature of the syndrome, has made it difficult to ascertain frequency, type, and natural history of the associated cardiac defects. It appears, however, that cardiac findings are clinically important and may be common. Moreover, the spectrum of heart disease is somewhat unique in that it includes not only congenital structural defects... You do not currently have access to this content.