Flick of the switch. We used an aptazyme and an anti-ribosome binding site (RBS) to construct a novel artificial ribozyme-based riboswitch that functions in E. coli (see figure). This riboswitch worked well at low temperature and activated its own ribozyme and gene expression in the presence of targets even though it is ribozyme based. We also improved the switching efficiency by constructing a cascading system.
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Ogawa et al. (2007) studied this question.
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