Summary. A modification of Ahlmark's method for the determination of histaminolytic activity of plasma during pregnancy is described. It is demonstrated that the lengthy and drastic chemical treatment of the plasma samples may be omitted. In principle the method described consists of three steps: Incubation at 37° C of a mixture containing plasma, histamine and Tyrode's solution. Withdrawal of samples at certain intervals and arrestment of histaminolysis by heating these samples to boiling point. Biological assay of the undecomposed histamine on isolated gut from a guinea‐pig. Histaminolytic activities as low as 0.006 γ/ml/h may be detected with this method. The error is 12–17 per cent.
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Finn Wicksell (1949) studied this question.