Key result
NOS, potassium channel, and epoxygenase inhibitors reduce flow-mediated radial artery dilatation versus saline.
Why the study?
The role of the balance between nitric oxide and endothelium-derived hyperpolarizing factor in regulating basal diameter and endothelium-dependent dilatation of conduit arteries in humans has been poorly assessed.
Do inhibitors of NO-synthase, calcium-activated potassium channels, and cytochrome epoxygenases alter radial artery basal diameter and endothelium-dependent dilatation in healthy volunteers?
Population
Healthy volunteers
Comparison
Infusion of L-NMMA, TEA, and fluconazole alone and in combination versus saline
Design
Physiological study measuring radial artery diameter and flow with echotracking and Doppler
Authors
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Supports balanced NO/EDHF regulation of conduit artery tone in health; leaves open therapeutic targeting in vascular disease.
Do inhibitors of NO-synthase, calcium-activated potassium channels, and cytochrome epoxygenases alter radial artery basal diameter and endothelium-dependent dilatation in healthy volunteers?
EDHF and NO act in balance to regulate basal diameter and endothelium-dependent dilatation in human peripheral conduit arteries.
Bellien et al. (2008) studied Healthy volunteers. L-NMMA, TEA, and fluconazole vs. Saline was evaluated on Radial artery diameter and flow-mediated dilatation. Inhibitors of NO-synthase, calcium-activated potassium channels, and cytochrome epoxygenases reduced flow-mediated radial artery dilatation compared with saline.
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