Population
Isolated donor vessels from gracilis muscle of female NO-deficient mice and rats, and endothelium-denuded…
Comparison
Shear stress applied to donor vessels in a… vs Absence of shear stress, or pretreatment with…
Design
Preclinical
Authors
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Animal data implicate EETs in flow-mediated hyperpolarization; hypothesis-generating for EDHF pathways, no practice change warranted.
Shear stress stimulates the release of EETs from endothelial cells, which act as endothelium-derived hyperpolarizing factors to hyperpolarize downstream smooth muscle cells independent of gap junctions.
Huang et al. (2005) studied this question.
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