Key result
Organ space surgical site infections after colorectal surgery linked to ~16-fold higher one-year mortality.
Why the study?
Postoperative infections following colorectal surgery and their impact on hospital admission duration and mortality require further characterization to guide prevention and treatment strategies.
Observational (n=378)
No
Odds Ratio: 16 (95% CI 6–43)
Absolute Event Rate: 37% vs 4%
Organ space surgical site infections following colorectal surgery are associated with significantly increased hospital stay and 1-year mortality.
High mortality with organ space SSIs after colorectal surgery merits attention; hypothesis-generating for prevention trials.
A retrospective case note review of postoperative infections within 30 days of colorectal surgery was completed. Surgical site infections (SSIs) were identified in 22% of patients (84/378), with other infections, e.g. urinary tract infections, identified in 18.3% of patients. SSIs, urinary and respiratory tract infections were all associated with increased durations of hospital admission compared with non-infected patients. Consideration should be given to postoperative surveillance for all infections, using antibiotic consumption as an objective outcome measure. Nine percent of patients developed an organ space SSI. Organ space SSIs were associated with the longest additional duration of hospital admission (15.5 days) and were the only infection associated with an increase in mortality at 1 year; 37% (13/35) mortality with an organ space SSI vs 4% (8/225) without an infection (odds ratio = 16, 95% confidence interval = 6, 43). Further research to prevent and treat organ space SSIs should be prioritized.
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Kirby et al. (2015) conducted an observational in Colorectal surgery (n=378). Organ space surgical site infection vs. No infection was evaluated on Mortality at 1 year (OR 16, 95% CI 6-43). Organ space surgical site infections following colorectal surgery were associated with increased 1-year mortality compared to no infection (37% vs 4%; OR 16, 95% CI 6-43).
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