Key result
High vital exhaustion is linked to elevated inflammatory markers in adults aged 25 to 44.
Why the study?
The association of vital exhaustion with biochemical markers of inflammation in young adults aged 25-44 years was not well characterized.
Cross-Sectional (n=975)
No
High vital exhaustion is associated with elevated systemic inflammatory markers (IL-6, TNF-α, MCP-1) in young and middle-aged adults, suggesting a potential biological mechanism linking psychosocial stress to cardiovascular disease.
Supports inflammation as pathway from vital exhaustion to early CVD risk; leaves open causal role and need for longitudinal confirmation.
Aim. To study the association of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) levels with vital exhaustion (VE) among men and women aged 25-44 years in Novosibirsk. Material and methods. At the Research Institute of Internal and Preventive Medicine (Novosibirsk), during 2013-2016, a cross-sectional survey of a random representative sample of people aged 25-44 years in one of the typical districts of Novosibirsk was carried out. A total of 975 individuals were examined (403 men, 530 women). The response rate was 71%. General examination and history collection were carried out according to standard methods included in the WHO program "MONICA-psychosocial (MOPSY)". All study participants completed the Maastricht Vital Exhaustion Questionnaire (MQ). Results. High and medium VE prevailed among women (15,7% and 40,6%) than among men (5,5% and 32,8%) (p<0,001). Median serum levels of IL-6 were high VE among both sexes 1,41 [0,70;4,60] pg/ml, compared with medium VE 1,20 [0,65;2,90] pg/ml, and low VE 1,12 [0,58;2,32] pg/ml (p<0,01), and among women with high VE 1,53 [0,72;4,33] pg/ml, compared with medium VE 1,14 [0,63;2,36] pg/ml and low VE 0,95 [0,50;1,98] pg/ml (p<0,05). Serum TNF-α was higher among women with high VE (6,01±3,23 pg/ml) than with medium VE (5,63±4,16 pg/ml) and low VE (4,95±2,85 pg/ml) (p=0,025). Mean serum MCP-1 levels among both sexes, men and women, were higher with high VE (324,55±161,89 pg/ml, 270,75±107,92 pg/ml and 338,81±171,1 pg/ml) than with medium (251,78±123,4 pg/ml, 262,46±134,9 pg/ml and 245,22±115,61 pg/ml), and low VE (227,59±101,03 pg/ml, 234,51±104,53 pg/ml and 220,17±96,81 pg/ml) (p<0,001). Conclusion. An increase in the average levels of inflammation biochemical markers (IL-6, TNF-α, MCP-1) was established in individuals 25-44 years old with a high VE.
No takes yet. Share an insight, caveat, or question.
Гафаров et al. (2023) conducted a cross-sectional in Vital exhaustion (n=975). High vital exhaustion vs. Medium and low vital exhaustion was evaluated on Serum levels of IL-6, TNF-α, and MCP-1 (p=<0.001). High vital exhaustion was associated with significantly increased average serum levels of inflammatory biochemical markers (IL-6, TNF-α, MCP-1) in individuals aged 25-44 years.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: