Key result
Nocturnal oxygen cuts elevated serum VEGF ~65% in patients with obstructive sleep apnea.
Why the study?
Repeated nocturnal hypoxia is implicated in cardiovascular complications in OSAS, and its effect on circulating VEGF levels was investigated.
Does nocturnal oxygen administration reduce circulating VEGF levels in patients with obstructive sleep apnea syndrome?
Population
24 OSAS patients and 24 age-matched controls
Comparison
Oxygen administration at 2 l/min vs compressed air administration during the night
Design
Randomized cross-over study
Follow-up
Overnight
Authors
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Suggests nocturnal oxygen as potential VEGF-lowering strategy in OSA; leaves open effects on cardiovascular outcomes.
RCT (n=48)
Randomly administered using a cross-over protocol
Yes
Does nocturnal oxygen administration reduce circulating VEGF levels in patients with obstructive sleep apnea syndrome?
Absolute Event Rate: 178% vs 515%
p-value: p=<0.01
Nocturnal oxygen administration significantly reduces elevated circulating VEGF levels in patients with obstructive sleep apnea syndrome, suggesting hypoxemia drives VEGF elevation.
Teramoto et al. (2003) conducted an RCT in Obstructive Sleep Apnea Syndrome (n=48). Oxygen administration vs. Baseline / Compressed air was evaluated on Serum VEGF levels after sleep (pg/ml) (p=<0.01). Nocturnal oxygen administration significantly decreased elevated serum VEGF levels from 515 pg/ml to 178 pg/ml in patients with obstructive sleep apnea syndrome.
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