Key result
Circulating microRNAs show promise as minimally invasive biomarkers to diagnose and monitor adrenal tumors.
Why the study?
The preoperative diagnosis of different adrenal tumors, including adrenocortical or adrenomedullary malignancy, is difficult, and circulating microRNAs might aid clinical management.
Can circulating microRNAs be used as biomarkers for the diagnosis and monitoring of adrenal tumors?
Can circulating microRNAs be used as biomarkers for the diagnosis and monitoring of adrenal tumors?
Circulating microRNAs represent promising minimally invasive biomarkers for the difficult preoperative diagnosis and monitoring of adrenal tumors.
Supports microRNA biomarker exploration in adrenal tumors; leaves open clinical adoption pending prospective validation.
PURPOSE OF REVIEW: Circulating microRNAs represent promising minimally invasive markers of several diseases including tumors. As the preoperative diagnosis of different adrenal tumors is difficult, for example, diagnosis of adrenocortical or adrenomedullary malignancy, circulating microRNAs might be helpful in their clinical management. RECENT FINDINGS: Observations regarding the applicability of circulating microRNAs isolated both from unfractionated plasma or serum and from extracellular vesicle preparations for the diagnosis of adrenocortical malignancy have been published. Data show that circulating microRNA might be exploited for monitoring adrenocortical cancer progression. Circulating microRNA profiles of adrenal myelolipoma have also been published that might be useful for differentiating adrenocortical cancer and adrenal myelolipoma in dubious cases. SUMMARY: In this review, recent advances in the field of circulating microRNAs in adrenal tumors are discussed.
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Péter Igaz (2019) conducted a review in Adrenal tumors. Circulating microRNAs was evaluated. Circulating microRNAs represent promising minimally invasive markers for the diagnosis and monitoring of adrenal tumors, including differentiating adrenocortical cancer and adrenal myelolipoma.
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