Key result
Intraoperative intravenous methadone did not significantly prolong QTc or increase the incidence of arrhythmias compared to other analgesics in adult cardiac surgical patients.
Why the study?
The effect of intraoperative intravenous methadone on perioperative corrected QT interval (QTc) and arrhythmia risk in adult cardiac surgical patients was uncertain.
Does intraoperative intravenous methadone increase the risk of postoperative QTc prolongation or arrhythmias in adult patients undergoing elective cardiac surgery?
Cohort (n=1,040)
No
Does intraoperative intravenous methadone increase the risk of postoperative QTc prolongation or arrhythmias in adult patients undergoing elective cardiac surgery?
A single intraoperative dose of intravenous methadone during cardiac surgery does not significantly prolong the QTc interval or increase the risk of arrhythmias.
Supports methadone safety regarding QTc/arrhythmias in this cohort; leaves open confirmation in randomized trials.
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McClain et al. (2024) conducted a cohort in Elective cardiac surgery (n=1,040). Intravenous methadone vs. Analgesics other than intravenous methadone was evaluated on Change in QTc and the percent QTc change between preoperative QTc and postoperative QTc upon intensive care unit admission. Intraoperative intravenous methadone did not significantly prolong QTc or increase the incidence of arrhythmias compared to other analgesics in adult cardiac surgical patients.
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