Key result
Pulsed field ablation carries a risk of coronary artery vasospasm near coronary arteries.
Why the study?
Pulsed field ablation for AF and AFL has a favorable safety profile but carries a risk of coronary artery vasospasm during ablation near coronary arteries.
Does high dose nitroglycerin prevent coronary artery spasm in patients undergoing arrhythmia ablation?
Does high dose nitroglycerin prevent coronary artery spasm in patients undergoing arrhythmia ablation?
Ablation in close proximity to coronary arteries carries a risk of vasospasm, which may potentially be mitigated by high dose nitroglycerin.
Pulsed field ablation (PFA) is an emerging modality for myocardial tissue ablation in the treatment of atrial fibrillation (AF) and atrial flutter (AFL). Its use has expanded due to a favorable safety profile and comparable efficacy relative to conventional thermal ablative techniques. Notably, PFA is associated with a reduced risk of esophageal injury, pulmonary vein stenosis, and phrenic nerve injury.1-3 However, ablation in close proximity to coronary arteries carries a risk of vasospasm.1-5
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Le et al. (2026) conducted a review in Atrial fibrillation and atrial flutter. High dose nitroglycerin was evaluated. Pulsed field ablation for atrial fibrillation and flutter carries a risk of coronary artery vasospasm when performed in close proximity to coronary arteries.
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