July 1, 2024Nature MedicineOpen Access

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

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Authors

EEEmmanuel EkanemInova Health System PNPetr NeužilElectrophysiology TRTobias ReichlinElectrophysiology

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Implication

Multicenter registry study reports low major complication rates with pulsed field ablation in atrial fibrillation patients, highlighting a favorable safety profile over thermal ablation.

Key Points

Low overall complication rates occurred following pulsed field ablation for atrial fibrillation, with no observed esophageal damage or persistent phrenic palsy.
Major complications occurred in approximately 1% of treated patients, with pericardial tamponade documented as the primary adverse event at 0.36% across the cohort.
Post-approval evaluation across 106 clinical centers evaluated procedural safety, indicating that pulsed field ablation may transform management of atrial fibrillation.

Cite This Study

Ekanem et al. (2024) studied this question.

synapsesocial.com/papers/68e61c93b6db6435875aeb8d https://doi.org/10.1038/s41591-024-03114-3

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Implication

Multicenter registry study reports low major complication rates with pulsed field ablation in atrial fibrillation patients, highlighting a favorable safety profile over thermal ablation.

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Discussion

Member takes

Implication

Key Points

Cite This Study

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Discussion

Member takes

Implication

Key Points

Cite This Study

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