1,3‐Dipolar Cycloaddition: Click Chemistry for the Synthesis of 5‐Substituted Tetrazoles from Organoaluminum Azides and Nitriles

Cheap and safe: Conventional methods to prepare tetrazoles employ dangerous, toxic reagents. A new route to these heterocycles (see scheme) uses inexpensive and nontoxic dialkyl aluminum azides. The cycloaddition occurs under mild conditions and tolerates a variety of functional groups. The low cost and ecocompatibility make this process attractive for large-scale preparation.