Key result
Streptozotocin-induced diabetes alters 51 aortic proteins, notably decreasing mitochondrial proteins.
Why the study?
The molecular mechanisms underlying diabetic arteriopathy remain poorly understood, necessitating identification of major proteins and pathways involved.
This proteomic analysis identifies specific protein and pathway alterations, such as oxidative stress and mitochondrial dysfunction, implicated in the pathogenesis of diabetic arteriopathy.
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Rat aortic proteome shifts implicate oxidative/mitochondrial pathways in diabetic arteriopathy; leaves open relevance to human disease.
Jüllig et al. (2010) studied Diabetic arteriopathy (n=16). Streptozotocin vs. Saline vehicle was evaluated on Changes in relative abundance of aortic proteins. Streptozotocin-induced diabetes significantly altered the relative abundance of 51 aortic proteins, notably decreasing mitochondrial proteins and altering oxidative stress responses and actomyosin.
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