Key result
hnRNP Q inhibits YB-1 mRNA translation by displacing PABP and enhancing YB-1 binding.
Why the study?
Proteins specifically interacting with the 3' UTR of YB-1 mRNA and their effects on YB-1 mRNA translation were not fully identified or understood.
In this study, proteins specifically interacting with the 3' untranslated region (UTR) of mRNA of the multifunctional Y-box-binding protein 1 (YB-1) were identified. One of these, hnRNP Q, was shown to specifically interact with the regulatory element (RE) in YB-1 mRNA 3' UTR and to inhibit translation of this mRNA. Its binding to the RE was accompanied by displacement from this element of the poly(A)-binding protein (PABP), a positive regulator of YB-1 mRNA translation, and by enhanced binding of the negative YB-1 mRNA translation regulator - YB-1 itself.
No takes yet. Share an insight, caveat, or question.
Lyabin et al. (2013) studied this question. hnRNP Q was evaluated on YB-1 mRNA translation. hnRNP Q specifically interacts with the regulatory element in YB-1 mRNA 3' UTR, inhibiting its translation by displacing PABP and enhancing YB-1 binding.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: