Key result
The IVC stenosis mouse model offers specific strengths and weaknesses for studying DVT mechanisms.
Why the study?
Many mouse models of thrombosis exist, but the strengths and weaknesses of the inferior vena cava stenosis model have not been summarized.
This communication provides a standardized summary of the strengths and weaknesses of the IVC stenosis mouse model for studying venous thrombosis.
Guides standardized use of IVC stenosis model in preclinical DVT studies; leaves open translation to human venous thrombosis.
Deep vein thrombosis (DVT) is a significant cause of morbidity and mortality throughout the world 1. Risk factors for DVT include major surgery, immobilization, trauma, and cancer, among others 1. Many mouse models of thrombosis have been used to study mechanisms of thrombosis, including those involving small and large veins. In this report from the Animal Models Subcommittee of the ISTH, we summarize the strengths and weaknesses of the inferior vena cava (IVC) stenosis mouse model of venous thrombosis.
No takes yet. Share an insight, caveat, or question.
Geddings et al. (2014) conducted a review in Deep vein thrombosis. Inferior vena cava (IVC) stenosis mouse model was evaluated. The inferior vena cava stenosis mouse model of venous thrombosis has specific strengths and weaknesses for studying mechanisms of deep vein thrombosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: